Enhancing effect of tumor promoter 12-O-tetradecanoylphorbol-13-acetate on 8-azaguanine-resistant mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in cultured chinese hamster cells.
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چکیده
منابع مشابه
The effect of ubenimex on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach tumor in rats.
The effect of ubenimex on the progression of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced stomach tumor in rats was studied. Tumor induction was performed by giving MNNG via drinking water for 34 weeks. Ubenimex was ip administered twice a week at 0.5 mg/kg for 84 weeks in one group and 49 weeks in another starting from the first and 36th weeks after initiation of MNNG administration, re...
متن کاملEffect of calcium on rat gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine.
The effect of calcium carbonate (CaCO3) on the initiation of gastroduodenal carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was examined under the conditions with and without sodium chloride. Male Wistar rats were given drinking water containing MNNG (100 mg/liter) and one of the following diets during the first 20 weeks ad libitum. Group 1 was given basal diet; group 2, d...
متن کاملEffect of tumor promoter 12-O-tetradecanoylphorbol-13-acetate on recovery of methotrexate-, N-(phosphonacetyl)-L-aspartate-, and cadmium-resistant colony-forming mouse and hamster cells.
The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and its nontumor promoting derivative 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate on the frequency of mouse and hamster cells resistant to methotrexate (MTX), N-(phosphonacetyl)-L-aspartate, and cadmium has been examined. TPA alone at concentrations up to 1.0 microgram/ml had no significant effect on the plating ef...
متن کاملIncreased persistence of induced mutants of Chinese hamster cells by 12-O-tetradecanoylphorbol-13-acetate.
Hypoxanthine phosphoribosyltransferase deficient mutants of Chinese hamster ovary cells induced by ethyl methanesulfonate usually do not maintain their phenotype during growth in non-selective medium immediately following the induction. This phenomenon, called poor "persistence" of the induced mutation, is in most cases unrelated to growth rate but results from establishment of contact with wil...
متن کاملChemically induced mutations in mitochondrial DNA of human cells: mutational spectrum of N-methyl-N'-nitro-N-nitrosoguanidine.
We have observed a reproducible mitochondrial mutational spectrum in the MT1 human lymphoblastoid line treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The MNNG spectrum was distinct from the spontaneous mutational spectrum. However, our ability to observe MNNG-induced mitochondrial mutations above the high level of accumulated spontaneous mutations was dependent on the MT1 phenotype. ...
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ژورنال
عنوان ژورنال: The Japanese Journal of Genetics
سال: 1981
ISSN: 0021-504X,1880-5787
DOI: 10.1266/jjg.56.9